Terpenes & The Entourage Effect: What’s all the Fuss

If you have a medicinal, recreational or scientific interest in the cannabis plant, the term “terpenes” has most likely popped up as you educate yourself on cannabis and the way it interacts with the human body.

The importance of terpenes in all species of plants, especially cannabis, can’t be underestimated. Terpenes are fundamental building blocks of the cannabis plant and have a very important and influential role to play in the plant’s overall biological makeup and all compounds that are derived from it.

What Exactly are Terpenes in Plant Science?

Terpenes are essential building blocks of many different plant varieties and are essentially what gives each plant their special aroma and flavor. Technically, terpenes are groupings of hydrocarbons that give plants their specific flavors and aromas.

Lemons are a fantastic example of illustrating the power of terpenes in a relatable way. Without terpenes, a lemon would not have the flavor and scent profile that we all associate with the lemon. It’s the terpene called Limonene that is responsible for that special flavor and aroma. Limonene is also a terpene that is present in cannabis.

Pinene is another example of a common terpene that is also present in cannabis. Pinene gives off an earthy smell that is very specific to many coniferous trees and bushes all around the world. When describing the scent and aroma of pine, some say the aroma is similar to vanilla. Others say that there are hints of butterscotch. In addition to its powerful scent and aromas, it produces many beneficial effects in the context of cannabis which we will cover below.

Common Terpenes In Cannabis & Their Aromas and Effects

Depending upon the strain of cannabis, there can be vast amounts of terpenes present. Each one is different and lends itself to a scent or flavor. And each one has different reported characteristics and benefits.

While there is a myriad of terpenes present in the cannabis sativa plant, more than 120 at current count, there are a few we should look at more closely, as they are showing extremely beneficial results for medical marijuana users.

Here are some of the notable terpenes found in cannabis:


Commonly found in the resin of coniferous trees like the pine tree, α-pinene (“Pinene”), a primary isomer, can be found in cannabis, sage, eucalyptus, olive, rosemary, sassafras, and bergamot, to name a few. β-pinene, a secondary isomer, is found in hops and cumin. Pinene is a very prevalent terpene and has been harvested for centuries, used in alternative and holistic healing.

Pinene’s benefits are numerous. It offers antioxidant, antibacterial, antibiotic, and anti-inflammatory properties. Pinene is also increasingly studied and recognized in the medical community for its ability to aid in the slowing of cancer cell growth. In addition, Pinene is also known for its expectorant and Broncho dilative properties, helping those with respiratory issues.

When present in the cannabis plant, Pinene is known to counteract the psychoactive effects of THC, helpful to those who prefer to stay grounded while undergoing its effects.


This is a spicy, often floral scent, found in many plants including mint, rosewood, lavender, and cinnamon. It has sedative and calming effects, used as a sleep aid for centuries.

Linalool is known for its anti-depressant, anxiolytic, and anti-inflammatory properties. It offers pain relief and is studied for its ability to inhibit cancer cell growth and regeneration.


Found in clove, basil, coriander, and hops (cannabis’s cousin), Humulene gives off an earthy, woody, and spicy aroma.

Humulene has been used in holistic healing for thousands of years because it possesses powerful anti-inflammatory and antibacterial properties and can be utilized as a pain reliever and tonic.


Found in apple, tea tree, cumin, some citrus fruits, oregano, and marjoram, this smoky and woody terpene is also common to the cannabis plant.

It is known for its sedative effects, as well as anti-bacterial, anti-fungal, and antioxidant properties.


Limonene, which we’re already familiar with, is one of the most common and well-known terpenes. Found in citrus rinds, juniper, and peppermint, Limonene can be found in numerous foods, fragrances, and household cleaners. Limonene is known for its strong citrus aroma.

Limonene possesses a wide array of benefits, including its overall beneficial effects on the entire gastrointestinal system. Limonene also has antidepressant, anxiolytic, anti-fungal, and anti-inflammatory properties. In addition to all that, it is also sometimes used as an anti-proliferative and immune-stimulant, helping to protect from the carcinogens found in smoke. Limonene also helps with mental focus, concentration, and clarity.

Terpenes & The Entourage Effect

Entourage Effect is a scientific way of describing the interactions between cannbionoids and terpenoids.  When combined together the cannabinoids and terpenoids generate interactive synergy.  The study of terpenoids in relation to cannabinoids is uncovering new findings as it pertains to the effectiveness of “whole plant medicine,” a term used to explain how cannabinoids and terpenes work together to provide symptomatic relief across a wide range of medical conditions and symptoms.

Although the benefits of terpenes are impressive in isolation, the Entourage Effect displays how, when combined with other terpenes or synergized with cannabinoids such as THC and CBD, that there is a definitive increase in beneficial properties, which means that the medicinal value of the cannabis plant drastically rises when the Entourage Effect comes into play.

When terpenes work together in harmony with cannabinoids, medicinal properties seem to augment their effectiveness, making the cannabis plant a true healer.

Research and Findings on The Entourage Effect

In 2010, Dr. Ethan Russo, a prominent neurologist, published his findings in the British Journal of Pharmacology. Dr. Russo studied the far-reaching effects of combining various compounds to produce the Entourage Effect. Different combinations include;

  • Individual– Allowing the terpene to product effects on its own. For instance, the terpene Myrcene helps to better allow chemical absorption by reducing resistance in the blood/brain barrier;
  • Combined with Other Terpenes- Using a combination of terpenes that produce similar effects to increase effectiveness. For example, some combine Pinene, Myrcene, and Caryophyllene with the belief that this combination effectively combats anxiety;
  • Combined with Other Cannabinoids- Directly combining terpenes with other parts of the cannabis plant such as CBD or CBD can create desired effects. For instance, combining the cannabinoid CBG with Linalool and Limonene may be an effective treatment against resistant staph infections such as MRSA

The Benefits of the Entourage Effect and a Call for Additional Research

Whole plant therapy is an increasingly more important category in medicine today. As science continues to study and reveal the benefits of the Entourage Effect and how cannabinoids exist on and perform at a molecular level, we are better able to learn how it affects the endocannabinoid system, both directly and indirectly.

Medically accessing the benefits of the Entourage Effect could greatly augment the positive and far-reaching potential that terpenes found in cannabis have on the body when they interact with other cannabinoids.

In short, terpenes are important. They have also been used for thousands of years in traditional remedies and herb-based medicines and now, thanks to technology and further research, we can finally understand the therapeutic benefits of terpenes so that they can take their rightful therapeutic place in science, health, and wellness.

Terpenes and the Strainprint App

The Strainprint app is evolving to ensure that medical marijuana users can access up to date data and accounts of others’ experiences with certain strains.

When researching your strains, do additional work to understand the terpenes that are present within each strain and the levels they exist in. Record your feelings and what you notice about the strain’s effectiveness when taking certain strains and be sure to record in the Strainprint app.

Together, we can add to the body of knowledge on terpenes and certain cannabis strains for medical marijuana through the Strainprint app!

Patient Profile – Mike Rudichuk – Replacing High Doses of Opioids with Cannabis for Back Pain

As the Strainprint community grows, we have the pleasure of meeting different people from across the country who rely on the app daily for their medical marijuana dosing and information.

Last Patient Profile, we featured the story of Jennifer Raymond, who suffers from psoriatic arthritis who found that cannabis was the key to helping her manage her regular pain while maintaining a high-degree of function as a busy working mother.

This month, we’re pleased to feature the story of Mike Rudichuk, who was generous enough to share his journey with cannabis and Strainprint with our team.  

Mike’s Journey

Mike became a medical cannabis patient 2 years ago as a result of chronic and debilitating pain due to herniated disks in his lower back that were impacting his daily life. As a young father of just 36 who has a full-time job, hobbies, and a household to run, Mike needed something to help take the edge off from the back pain that was impacting every aspect of his life. Like many other Canadians, he turned to opioid painkillers to help manage his pain.

He found that his body was becoming highly tolerant of the pain medications, requiring an increase in his doses regularly. His pain wasn’t being managed as much as just masked, and he was feeling that the strong chemicals in the pharmaceuticals were taking a negative toll on his overall health. The side effects he experienced didn’t seem worth the struggle. Concerned about this, when found that if he tried to lower his doses, or even take time away from the prescriptions, he’d experience withdrawal. He began to be concerned about his long-term health and how his body would be able to manage going off the opioids entirely. It was time to look for an alternative.

Through open dialogue with his own Family Doctor, Mike decided to try medical cannabis as an alternative to the strong opioids he was using. Luckily, his doctor even committed to walking this journey with him so that he could understand how medical cannabis would make a difference in his pain management.

Within a few months, Mike found that he had made more progress managing his pain using certain cannabis strains than he ever had over years of using pain pills. Mike prefers to use low-THC high-CBD strains like Zen’s Garden from Emblem.

He vapes, usually in the mornings and afternoons to help get through the days. The lower THC in small doses helps him attack his pain without a loss of clarity, whereas he felt like he was in “outer space” with opioid use.

When asked about his journey in pain management, Mike says, “If there is one thing I could change, it would have been to start using medical cannabis sooner.”

Mike & Strainprint

Mike was an early user of Strainprint and recalls a time where customer service exceeded his expectations. After sending a Tweet to Strainprint making some suggestions about the app, he was connected with Strainprint’s CEO, David Berg, where there was an acknowledgment of feedback and an intentional effort to address upcoming software updates for the continuous improvement of the app. “Anytime a CEO takes time to personally respond to clients, you know you’re in the right place,” Mike says about his experience, “The wonderful people at Strainprint are patients like us, so they take feedback very seriously.”

Mike finds that tracking his daily regime helps him greatly to feel in control of his pain management, which is incredibly big deal to someone who has come off opiods.

Mike’s Advice

Mike has the following advice for those interested to try medical cannabis for the first time:

“Don’t be afraid to talk to your doctor. It’s your body and your life, and you should be well aware of all treatment options including cannabis. I can use cannabis at any point of the day and not impair me to the point of not being able to function, whereas there were times with pain medications where I was so zoned out and not able to function properly. I’ve been given a better quality of life and have felt much better in general health overall since being off opioid pain-killers and using medical cannabis.”

Strainprint™ Technologies Ltd. (“Strainprint”) Expands Nationwide Coverage With the Addition of Harvest Medicine to The Strainprint Community


Toronto, August 2, 2017 – Strainprint, the leader in cannabis data collection and strain efficacy reporting [analytics], is pleased to welcome Harvest Medicine cannabis clinic to its growing list of data customers. Based in Calgary, Alberta, Harvest Medicine (“Harvest”) is a world-class medical cannabis clinic with a focus on education and 360-degree patient wellness. Their state-of-the art educational resource centre hosts events, workshops to help create a sense of community for medical cannabis patients and those who love and support them in their health goals.

“In our search for resources to better serve our patients, we found Strainprint to have the most comprehensive and granular source of strain efficacy data. We will use this data to validate our existing knowledge base and to help shape our education initiatives,” said the CEO of Harvest Medicine. “Plus, the simple interface, breadth of symptom and strain coverage and ease of reporting make the Strainprint app the perfect value-add companion tool for our passionate patients.”

Harvest will begin promoting the Strainprint app to its 5,000+ cannabis patients immediately through a unique activation code. Patients are encouraged to log their medication sessions to track which strains work best for their symptoms. On each clinic visit patients share their detailed outcomes reports with their doctor and together determine optimal treatment for overall wellness.

“We are so excited to work with the Harvest team to develop education programs and to help optimize our web-based clinical analytics platform. From the first moment we met the Harvest team, we could see their forward-thinking, fact-based approach to patient care. We’re here to support them,” said Strainprint C.E.O., Andrew Muroff.

The Strainprint App can be downloaded from both the iOS App Store and GooglePlay Store.

About Strainprint™

Founded in Toronto in 2016, StrainprintTM Technologies Ltd. is a Toronto-based software company providing enterprise grade analytics and consumer solutions for the medical cannabis industry. Strainprint manages the gathering and analysis of real-time cannabis consumption data and ranks specific strain efficacy against conditions and related symptoms. StrainprintTM data supports cannabis researchers globally and provides advanced intelligence to licensed producers to optimize grow operations and to clinics to improve treatment recommendations. For more information visit www.strainprint.ca, facebook, twitter, linkedin

Media Contact

Jessica Moran
Strainprint Technologies Ltd.